AppDomain

AssemblyLoad

            SplashScreen splash = new SplashScreen();
            new Thread(delegate()
            {
                AppDomain mainAppDomain = AppDomain.CreateDomain("MainApp");
                mainAppDomain.AssemblyLoad += (s, e) => { };
                //MessageBox.Show(e.LoadedAssembly.GetName().Name);
                mainAppDomain.ExecuteAssembly(args[0]);
            }).Start();

        static void Main(string[] args)
        {
            Application.EnableVisualStyles();
            Application.SetCompatibleTextRenderingDefault(false);
            Application.Run(new SplashScreen());

        }

        public SplashScreen()
        {
            InitializeComponent();
            Thread mainApp = new Thread(delegate()
            {
                AppDomain mainAppDomain = AppDomain.CreateDomain("MainApp");
                mainAppDomain.AssemblyLoad += (s, e) => { };
                //MessageBox.Show(e.LoadedAssembly.GetName().Name);
                Mutex mut = new Mutex(true, "LOCAL//Client");
                mainAppDomain.ExecuteAssembly("Client.exe");
            });

            Shown += (s, e) =>
            {
                mainApp.Start();
                Thread.Sleep(2000);
                Mutex mut = new Mutex(false, "LOCAL//Client");
                mut.WaitOne();
                Close();
            };
        }